Maybe I'm just very agreeable but I agree with all 3 replies:
1. The Weber is a super little carb, I used to collect them like lug nuts back in the day, great MPG and very tunable too.
And, any place I've run a Holley, I've always seen another carb get better MPG on that same car - Rochester, Autolite, etc.
2. On the other hand, it is true the 600 Holley is everywhere, this would be a good experiment.
3. At first I didn't agree with the comment about the "designed as a 4 barrel" but then thought it through. Here is the part that might be tricky:
You could block off the throttle plates and fuel and air and idle fuel circuits on one side, fine.
Now you have a progressive 2-barrel. I see no other issues except one:
When will the secondary open?
As I recall it's the choke side of the carb that sends the signal to open the secondary, and sometimes there is a signal hole in BOTH the primary and secondary venturi. THESE are in fact designed to open BOTH secondaries, when they decide that BOTH primaries are overextended. Would these same signals open the secondary properly with the throttle side blocked off?
Maybe, maybe not.
I see no harm in trying it, the secondary will either not open soon enough or bog from opening too soon.
In a light car with steep gears you could probably even get away with connecting the secondary mechanically and hope it doesn't bog from lack of pump shot.
Hey, go for it and let us know!